Peptide receptor imaging of prostate cancer with radiolabelled bombesin analogues
نویسندگان
چکیده
منابع مشابه
Peptide receptor imaging of prostate cancer with radiolabelled bombesin analogues.
Prostate Cancer (PC) is a type of cancer that is often diagnosed at very early stages due to improved detection among man in the Western world. Current imaging techniques are not optimal to determine extent of minimal early stage PC even though this is of great clinical importance. Human PC and high-grade PIN have shown high Gastrin-Releasing Peptide Receptor (GRPR) expression, while normal pro...
متن کاملمطالعه درون تنی و برون تنی مشتق جدیدی از بومبزین با فاصله دهنده تری گلایسین به عنوان عامل بالقوه در تصویربرداری هدفمند تومور
Background and purpose: Bombesin is a 14-amino acid peptide with high biological functions which has a high affinity to GRP )Gastrin releasing peptide( receptor. GRP receptors are overexpressed in many malignant tumors such as prostate and breast cancers. The purpose of this study was to prepare [HYNIC-(Gly)3-D-Phe13]Bombesin(7-14) to label it easily by 99mTc and to evaluate it as a potential a...
متن کاملAntitumoral activity of bombesin analogues on small cell lung cancer xenografts: relationship with bombesin receptor expression.
Gastrin releasing peptide (GRP), the human homologue of bombesin (BN), is an autocrine growth factor for small cell lung cancer (SCLC) cells. The synthetic octapeptides [D-cpa1-beta-Leu8-des-Met9]litorin (BIM 26182) and [D-Phe6-Leu13-CH2NH-Cpa14]bombesin(6-14)NH2 (BIM 26189) are potent GRP/BN antagonists of the proliferation of 3T3 and rat pancreas cells. The effect of these analogues on the pr...
متن کاملTargeting prostate cancer with radiolabelled bombesins
The fact that a number of common human tumours, including those of breast and prostate, express increased levels of the gastrin-releasing peptide receptor (GRP-R) means that this receptor is a potential target for peptide receptor mediated scintigraphy and targeted radionuclide therapy. Although clinical application is yet in its infancy, there is a considerable literature on preclinical studie...
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Radiology requires a mass of tissue, displacing tissue, infiltrating tissue, for contrast. Nuclear Medicine does not require a mass. It exploits the subtle differences between the cancer cell and the normal cell for identification. There is also an amplification factor. For example, antigen expression may be 500–50,000 per cell and receptor expression may be between 500 and 10,000 per cell. The...
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ژورنال
عنوان ژورنال: Methods
سال: 2009
ISSN: 1046-2023
DOI: 10.1016/j.ymeth.2009.04.002